Research & Publications
New
Article
Full-text available
Hemocompatibility and Long-Term Outcomes in HeartWare Versus HeartMate II Versus HeartMate 3: Multicenter Real-World Cohort
2026
Artificial Organs
Hamza H. H. Ben Nasir
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Ahmed F. A. Mohammed
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Omar Allham
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[...]
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Rashad Zayat
Abstract
Background
To compare overall and hemocompatibility-related outcomes across third-generation centrifugal-flow HeartMate 3 (HM3) versus second-generation axial-flow HeartMate II (HMII) and centrifugal-flow HeartWare (HVAD) in routine clinical practice.
Methods
We conducted a multicenter observational cohort of adult LVAD recipients (n = 327: HVAD n = 112, HMII n = 142, HM3 n = 73). Baseline characteristics and perioperative variables were recorded. Overall survival was analyzed using Kaplan–Meier and Cox proportional hazards models with HM3 as reference. Hemocompatibility-related adverse events (HRAE; pump thrombosis, ischemic stroke, major bleeding) were assessed with cumulative incidence functions (Aalen–Johansen) and Fine–Gray competing-risk regression with death as a competing event; the hemocompatibility score (HCS) summarized event burden over follow-up.
Results
HM3 demonstrated superior long-term survival compared with both HMII and HVAD in Kaplan–Meier analyses (log-rank p 
To compare overall and hemocompatibility-related outcomes across third-generation centrifugal-flow HeartMate 3 (HM3) versus second-generation axial-flow HeartMate II (HMII) and centrifugal-flow HeartWare (HVAD) in routine clinical practice.
Methods
We conducted a multicenter observational cohort of adult LVAD recipients (n = 327: HVAD n = 112, HMII n = 142, HM3 n = 73). Baseline characteristics and perioperative variables were recorded. Overall survival was analyzed using Kaplan–Meier and Cox proportional hazards models with HM3 as reference. Hemocompatibility-related adverse events (HRAE; pump thrombosis, ischemic stroke, major bleeding) were assessed with cumulative incidence functions (Aalen–Johansen) and Fine–Gray competing-risk regression with death as a competing event; the hemocompatibility score (HCS) summarized event burden over follow-up.
Results
HM3 demonstrated superior long-term survival compared with both HMII and HVAD in Kaplan–Meier analyses (log-rank p 
New
Article
Full-text available
Sex-Related Differences in Prosthesis-Patient Mismatch Following Aortic Valve Replacement with Perceval Sutureless Valve
2026
Journal of Cardiovascular Development and Disease
Ali Aljalloud
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Yusuf Shieba
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Rashad Zayat
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[...]
·
Ahmed Farghal Ahmed Mohammed
Abstract
(1) Background: Prosthesis–patient mismatch (PPM) after aortic valve replacement (AVR) impairs left ventricular (LV) recovery and is more common in women due to smaller aortic dimensions. Although the Perceval sutureless valve provides larger effective orifice areas, sex-specific PPM outcomes remain unclear. This study evaluated sex-related differences in PPM incidence, severity, and early impact after Perceval AVR. (2) Methods: We retrospectively analyzed 139 patients (68 males, 71 females) who underwent Perceval AVR between 2016 and 2020. PPM was defined per Valve Academic Research Consortium-3 (VARC-3) criteria using indexed effective orifice area (EOAi) and stratified by body-mass-index (BMI) (
